6 ms·

Can you please explain the neuronal mechanisms involved in this frying? If you have citations I would love to read more.

an-allen 5y ago
So yea you put the neurons in a hot cast iron skillet, with a nice mix of butter and onions and viola - fried neurons. You can use this to baste most white meats like chicken, pork, or fish. Just please be aware that some nervous system matter has been shown to transmit prion type diseases -> so you want to make quadruply sure you got your fried neurons from a reputable dealer who has strict health controls.
- monetus 5y ago
  You jest but my grandfather loved brains. I think it might have been a ww2 Alaskan thing? Idk. Ate them whenever he could.
  - Snoozus 5y ago
    Brain is delicious, umami panna cotta.
patrec 5y ago
Here's a citation for a drug Shulgin is famous for: > MDMA provides an immediate enjoyable feeling by stimulating the release of neurotransmitters, such as dopamine and serotonin in the brain. Unfortunately, abnormal regulation of the brain neurotransmitters, as well as the increased oxidative stress causes damage to the brain neurons after the MDMA exposure. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878040/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878040/
- netizen-936824 5y ago
  All of those studies are either in rats or mice or are in vitro. A lot of the mice and rat studies can't be translated to humans because they have significantly different metabolisms and researchers use entirely different dosages than humans do in the wild >MDMA has been administered to approximately 1,700 human subjects with only one serious adverse reaction. https://maps.org/mdma/ https://maps.org/mdma/ There are currently human studies of MDMA. These would probably not be moving forward if they found "brain frying" although I appreciate your willingness to read abstracts
  - eurasiantiger 5y ago
    Overdosing on MDMA can cause serotonin syndrome, which can cause neuronal death due to excitotoxicity.
    - netizen-936824 5y ago
      Overdose on many substances is bad and can damage neurons if it crosses the BBB. That's not saying anything special about entactogens/empathogens/psychedelics
      - eurasiantiger 5y ago
        I agree.
    - Terry_Roll 5y ago
      And thats the come down after popping a pill or two at some rave in the middle of field in Essex. Fortunately the body doesnt stop making new brain cells provided one's diet is adequate. I was surprised to learn the US Military resurrected MDMA in the 50's and then in the 70's Prof Alex Shulgin got hold of it. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931692/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931692/ Other country's handled it differently. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435835/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435835/ But it does lend credence to the conspiracy theory that the British security services started flooding the football terraces to reduce the football hooliganism that was blighting the British isles, as "documented" by later films like Football Factory starring Danny Dyer and many more. Still without it, would the world have what the US call EDM and what others call the Rave culture?
    - jaminal 5y ago
      This is very likely false; a myth perpetuated from the war on drugs combined with people taking unknown, untested substances in recreational settings. If they experienced serotonin syndrome it was quite easy to just point at the reported seratonergic substance that had been ingested (and which also may not have been present at all, depending on the source). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931730/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931730/

an-allen 5y ago

So yea you put the neurons in a hot cast iron skillet, with a nice mix of butter and onions and viola - fried neurons. You can use this to baste most white meats like chicken, pork, or fish. Just please be aware that some nervous system matter has been shown to transmit prion type diseases -> so you want to make quadruply sure you got your fried neurons from a reputable dealer who has strict health controls.

monetus 5y ago
You jest but my grandfather loved brains. I think it might have been a ww2 Alaskan thing? Idk. Ate them whenever he could.
- Snoozus 5y ago
  Brain is delicious, umami panna cotta.

patrec 5y ago

Here's a citation for a drug Shulgin is famous for: > MDMA provides an immediate enjoyable feeling by stimulating the release of neurotransmitters, such as dopamine and serotonin in the brain. Unfortunately, abnormal regulation of the brain neurotransmitters, as well as the increased oxidative stress causes damage to the brain neurons after the MDMA exposure. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878040/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878040/

netizen-936824 5y ago
All of those studies are either in rats or mice or are in vitro. A lot of the mice and rat studies can't be translated to humans because they have significantly different metabolisms and researchers use entirely different dosages than humans do in the wild >MDMA has been administered to approximately 1,700 human subjects with only one serious adverse reaction. https://maps.org/mdma/ https://maps.org/mdma/ There are currently human studies of MDMA. These would probably not be moving forward if they found "brain frying" although I appreciate your willingness to read abstracts
- eurasiantiger 5y ago
  Overdosing on MDMA can cause serotonin syndrome, which can cause neuronal death due to excitotoxicity.
  - netizen-936824 5y ago
    Overdose on many substances is bad and can damage neurons if it crosses the BBB. That's not saying anything special about entactogens/empathogens/psychedelics
    - eurasiantiger 5y ago
      I agree.
  - Terry_Roll 5y ago
    And thats the come down after popping a pill or two at some rave in the middle of field in Essex. Fortunately the body doesnt stop making new brain cells provided one's diet is adequate. I was surprised to learn the US Military resurrected MDMA in the 50's and then in the 70's Prof Alex Shulgin got hold of it. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931692/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931692/ Other country's handled it differently. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435835/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435835/ But it does lend credence to the conspiracy theory that the British security services started flooding the football terraces to reduce the football hooliganism that was blighting the British isles, as "documented" by later films like Football Factory starring Danny Dyer and many more. Still without it, would the world have what the US call EDM and what others call the Rave culture?
  - jaminal 5y ago
    This is very likely false; a myth perpetuated from the war on drugs combined with people taking unknown, untested substances in recreational settings. If they experienced serotonin syndrome it was quite easy to just point at the reported seratonergic substance that had been ingested (and which also may not have been present at all, depending on the source). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931730/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931730/