10 ms·
> I don't see psychedelics, and their use, as being particularly risky to physical health Maybe if you don't count frying your brain as a risk to your physical
by patrec 5y ago
> I don't see psychedelics, and their use, as being particularly risky to physical health
Maybe if you don't count frying your brain as a risk to your physical health.
- antihero 5y agoIs it really fried though? If I didn't want to "fry my brain" I would opt not to participate in this clusterfuck we call modern life.
- netizen-936824 5y agoCan you please explain the neuronal mechanisms involved in this frying? If you have citations I would love to read more.
- an-allen 5y agoSo yea you put the neurons in a hot cast iron skillet, with a nice mix of butter and onions and viola - fried neurons. You can use this to baste most white meats like chicken, pork, or fish. Just please be aware that some nervous system matter has been shown to transmit prion type diseases -> so you want to make quadruply sure you got your fried neurons from a reputable dealer who has strict health controls.
- patrec 5y agoHere's a citation for a drug Shulgin is famous for: > MDMA provides an immediate enjoyable feeling by stimulating the release of neurotransmitters, such as dopamine and serotonin in the brain. Unfortunately, abnormal regulation of the brain neurotransmitters, as well as the increased oxidative stress causes damage to the brain neurons after the MDMA exposure. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878040/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878040/
- netizen-936824 5y agoAll of those studies are either in rats or mice or are in vitro. A lot of the mice and rat studies can't be translated to humans because they have significantly different metabolisms and researchers use entirely different dosages than humans do in the wild >MDMA has been administered to approximately 1,700 human subjects with only one serious adverse reaction. https://maps.org/mdma/ https://maps.org/mdma/ There are currently human studies of MDMA. These would probably not be moving forward if they found "brain frying" although I appreciate your willingness to read abstracts
- eurasiantiger 5y agoOverdosing on MDMA can cause serotonin syndrome, which can cause neuronal death due to excitotoxicity.
- netizen-936824 5y agoOverdose on many substances is bad and can damage neurons if it crosses the BBB. That's not saying anything special about entactogens/empathogens/psychedelics
- eurasiantiger 5y agoI agree.
- Terry_Roll 5y agoAnd thats the come down after popping a pill or two at some rave in the middle of field in Essex. Fortunately the body doesnt stop making new brain cells provided one's diet is adequate. I was surprised to learn the US Military resurrected MDMA in the 50's and then in the 70's Prof Alex Shulgin got hold of it. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931692/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931692/ Other country's handled it differently. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435835/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435835/ But it does lend credence to the conspiracy theory that the British security services started flooding the football terraces to reduce the football hooliganism that was blighting the British isles, as "documented" by later films like Football Factory starring Danny Dyer and many more. Still without it, would the world have what the US call EDM and what others call the Rave culture?
- dspearson 5y agoModern society does a pretty good job of that already. How many prescriptions for antidepressants do we issue in the western world? tl;dr, I consider them lower risk than horse riding, or working in a startup.
- grapeskin 5y agoMost 78 year old men who aren't dead don't really have the mental faculties to clearly lecture a university at 78. A soda a day rots far more brains than an occasional trip.
- esperent 5y agoOr even a lot of trips, judging by all the famous old psychonauts who were still lecturing in their 70s, 80s, 90s, and even 100s.
- spacemanmatt 5y agoAnd the less-famous old psychonauts now training your EMS/fire staff, running software departments, working as school principals, etc. Don't forget about the rank and file!
- dr_dshiv 5y ago100%. Here’s a book of interviews of elderly psychonauts. https://books.google.nl/books?id=wL5G8s3xpxwC&lpg=PR11&ots=wk6201bV39&dq=info%3Ajoy0aNvqqKUJ%3Ascholar.google.com%2F&lr&pg=PR11#v=onepage&q=2cb&f=false https://books.google.nl/books?id=wL5G8s3xpxwC&lpg=PR11&ots=w...
- ASalazarMX 5y agoLove how pretentious the term "psychonaut" sounds. Edit: I'm not a smoker, I'm a toxicnaut.
- spacemanmatt 5y agoWhen the DARE officer said stuff like this to us as 7th graders, we laughed. It's maybe less funny today but ridicule remains the appropriate response.
- dkarl 5y agoThe DARE officer said drugs would fry your brain, and the kids taking and selling drugs said it was a lie to stop people from having an easy harmless good time. Considering the drugs that kids were taking at my high school, I wouldn't say either side covered themselves in glory.
- spacemanmatt 5y ago> I wouldn't say either side covered themselves in glory. heh. that's mostly fair, though DARE waged a propaganda campaign entirely unmatched by teenage druggies, who are mostly just people trying to get by.