3 ms·
He died at 88. Didn’t have heart trouble till 82. Didn’t have dementia till 86. And he took more (types of) drugs than any human ever. So, he was just a little
by dr_dshiv 5y ago
He died at 88. Didn’t have heart trouble till 82. Didn’t have dementia till 86. And he took more (types of) drugs than any human ever. So, he was just a little bit more healthy than average, no?
Edit: Thanks for sending me down the 5-HT2b rabbit hole. This was the cause of the Phen-Fen appetite suppressant heart issues. All psychedelics do seem to affect 5-HT2b receptors. I assume this is a dose dependent effect—where a daily high dose of Phen-Fen would be much more dangerous than occasional low weight psychedelic doses. But I appreciate the grounded caution and more research is clearly needed, ideally before I’m 70+.
- anaisbetts 5y agoIndeed, I would not really worry about this given how most people use psychs, but since you mentioned "in your old age", I thought I'd mention some effects that might be more problematic at that age vs. the average person today
- caslon 5y agoThe average American male dies at 74.2 as of 2020: https://www.cdc.gov/nchs/products/databriefs/db427.htm https://www.cdc.gov/nchs/products/databriefs/db427.htm
- danielvaughn 5y agoYeah, at that age it doesn't really matter what kills you - a life that long is something to be celebrated.
- subpixel 5y agoAll SSRIs are 5-HT2b agonists, apparently. Do people taking antidepressants have a higher instance of heart disease?
- SpodGaju 5y agoProzac is an antagonist (not agonist) of the 5HT2C receptor at higher doses. At lower doeses the increased serotonin from SERT inhibition will stimulate 5HT2C. https://www.pnas.org/doi/pdf/10.1073/pnas.94.5.2036 https://www.pnas.org/doi/pdf/10.1073/pnas.94.5.2036
- refurb 5y agoAll a matter of selectivity. Most drugs affecting the Sheraton in receptions have nanomolar or better selectivity for 5-ht2A, while 1000x less binding at 5-ht2b, which in biological terms is almost inactive at normal dosing.