2 ms·
That seems low -- 4 grams is the max daily dose for OTC acetaminophen. According to this [1] the minimum single dose toxicity for APAP is more like 7.5 to 12 g
by rootusrootus 5y ago
That seems low -- 4 grams is the max daily dose for OTC acetaminophen.
According to this [1] the minimum single dose toxicity for APAP is more like 7.5 to 12 grams. Finding a value for a lethal hydrocodone dose is more difficult, but I did see 90 mg mentioned.
For the dose of Vicodin you specified, 90mg of hydrocodone would correspond to 9 grams of APAP. So it's a race that it looks like either one could win.
[1] https://www.uspharmacist.com/article/acetaminophen-intoxication-a-criticalcare-emergency https://www.uspharmacist.com/article/acetaminophen-intoxicat...
- TylerE 5y agoThe difference is you can build a tolerance to opioids, so the LD of hydrocodone in an addict (or even just someone using for an extended period medically) will be FAR higher than in an opiod-naive person. Opioids kill via respiratory depression, not by destroying your organs.
- netizen-936824 5y ago>The United States FDA clearly states “severe liver damage may occur if you take more than 4000 mg of acetaminophen in 24 hours.” >There is no question that the upper threshold on the maximum daily allowed dose of APAP has been the subject of controversy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913076/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913076/