3 ms·

I also wonder where the idea that the FDA 'denatures' hydrocodone with acetaminophen comes from. AFAICT, if you overdose on vicodin it's more likely the hydroc

I also wonder where the idea that the FDA 'denatures' hydrocodone with acetaminophen comes from. AFAICT, if you overdose on vicodin it's more likely the hydrocodone will kill you before the acetaminophen.

netizen-936824 5y ago
This is entirely false. You can overdose from ~4 grams of APAP which you can ingest by taking 6 7.5/750 hydrocodone/APAP tablets That's not nearly enough hydrocodone to kill you
- rootusrootus 5y ago
  That seems low -- 4 grams is the max daily dose for OTC acetaminophen. According to this [1] the minimum single dose toxicity for APAP is more like 7.5 to 12 grams. Finding a value for a lethal hydrocodone dose is more difficult, but I did see 90 mg mentioned. For the dose of Vicodin you specified, 90mg of hydrocodone would correspond to 9 grams of APAP. So it's a race that it looks like either one could win. [1] https://www.uspharmacist.com/article/acetaminophen-intoxication-a-criticalcare-emergency https://www.uspharmacist.com/article/acetaminophen-intoxicat...
  - TylerE 5y ago
    The difference is you can build a tolerance to opioids, so the LD of hydrocodone in an addict (or even just someone using for an extended period medically) will be FAR higher than in an opiod-naive person. Opioids kill via respiratory depression, not by destroying your organs.
  - netizen-936824 5y ago
    >The United States FDA clearly states “severe liver damage may occur if you take more than 4000 mg of acetaminophen in 24 hours.” >There is no question that the upper threshold on the maximum daily allowed dose of APAP has been the subject of controversy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913076/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913076/