4 ms·

From what I've read, d-amphetamine[0] was the decongestant of choice for much of the 20th century. It's just that the counterculture weirdos were abusing it and

From what I've read, d-amphetamine[0] was the decongestant of choice for much of the 20th century. It's just that the counterculture weirdos were abusing it and that led to its restriction. Compared to pseudoephedrine its way more useful with minimal side effects like drinking a cup of coffee. [0]https://www.theatlantic.com/health/archive/2012/04/the-lost-world-of-benzedrine/255904/ https://www.theatlantic.com/health/archive/2012/04/the-lost-...

nimish 5y ago
Counterculture weirdos and Paul Erdos
erosenbe0 5y ago
That's dangerous to think it's the same as coffee. You can have a daily coffee when pregnant but we don't know about a daily dl-amphetamine. Not even close to the same side-effect profile. Coffee doesn't dilate your eyes, for starters. It's just not the same as a dopaminergic
- astrange 5y ago
  Dexedrine is a normal ADHD medicine so this has been studied and it seems fine. eg https://journals.sagepub.com/doi/10.1177/1087054719896857 https://journals.sagepub.com/doi/10.1177/1087054719896857
  - erosenbe0 5y ago
    This is really good news but hardly a comprehensive meta analysis over thousands of infants.
    - astrange 5y ago
      Well, it's not the only study, it's just an example. I think it was already generally considered safe but doctors were worried it might be passed on through breastfeeding.
      - erosenbe0 5y ago
        Sure but I would not equate with coffee which empirically we know can be well-tolerated by most of the population basically from birth to death. Adderall (dl mixture) is just not the same. We know Adderall tends to exacerbate acne and some forms of dermatitis but we don't know how much. We don't know if the pupil effects contribute to driving incidents. We don't know if dry mouth from Adderall is worse for dental health than the dry mouth that some people get after heavy espresso or other stimulating substances, like pseudoephedrine. We don't think the risk of paranoid behavior is high but it is higher than coffee, of course. And of course some not insignificant portion of the population can tolerate coffee or pseudoephedrine, but we're not too sure about Adderall. Schizophrenic, bipolar, OCD individuals, those with tics, tachycardia, etc, need to tread carefully with stimulants, even maybe sudafed.
joecool1029 5y ago
I mentioned in my last comment that Sudafed had effects in treating my ADHD. Ultimately I couldn't use it this way more than a few days a week or I'd get lower back pain. I've also tried steeping ephedra tea but did not notice any effects on concentration. Later on when I was formally diagnosed and prescribed proper meds I was placed on Adderall first and had similar unwanted side effects after a time. Ultimately, I settled on Dexedrine and no more side effects (other than insomnia if I take it too late) and haven't felt a need to up the dose for years now. It does still have decongestant effects like the other two. Considering I'm caffeine dependent and can't cycle off daily intake without crippling headaches, where I cycle Dexedrine off on the weekends/holidays without any withdrawal effects, I'd have to agree: So long as it's a therapeutic dose it's on-par or safer than coffee.

nimish 5y ago

Counterculture weirdos and Paul Erdos

erosenbe0 5y ago

That's dangerous to think it's the same as coffee. You can have a daily coffee when pregnant but we don't know about a daily dl-amphetamine. Not even close to the same side-effect profile. Coffee doesn't dilate your eyes, for starters. It's just not the same as a dopaminergic

astrange 5y ago
Dexedrine is a normal ADHD medicine so this has been studied and it seems fine. eg https://journals.sagepub.com/doi/10.1177/1087054719896857 https://journals.sagepub.com/doi/10.1177/1087054719896857
- erosenbe0 5y ago
  This is really good news but hardly a comprehensive meta analysis over thousands of infants.
  - astrange 5y ago
    Well, it's not the only study, it's just an example. I think it was already generally considered safe but doctors were worried it might be passed on through breastfeeding.
    - erosenbe0 5y ago
      Sure but I would not equate with coffee which empirically we know can be well-tolerated by most of the population basically from birth to death. Adderall (dl mixture) is just not the same. We know Adderall tends to exacerbate acne and some forms of dermatitis but we don't know how much. We don't know if the pupil effects contribute to driving incidents. We don't know if dry mouth from Adderall is worse for dental health than the dry mouth that some people get after heavy espresso or other stimulating substances, like pseudoephedrine. We don't think the risk of paranoid behavior is high but it is higher than coffee, of course. And of course some not insignificant portion of the population can tolerate coffee or pseudoephedrine, but we're not too sure about Adderall. Schizophrenic, bipolar, OCD individuals, those with tics, tachycardia, etc, need to tread carefully with stimulants, even maybe sudafed.

joecool1029 5y ago

I mentioned in my last comment that Sudafed had effects in treating my ADHD. Ultimately I couldn't use it this way more than a few days a week or I'd get lower back pain. I've also tried steeping ephedra tea but did not notice any effects on concentration. Later on when I was formally diagnosed and prescribed proper meds I was placed on Adderall first and had similar unwanted side effects after a time. Ultimately, I settled on Dexedrine and no more side effects (other than insomnia if I take it too late) and haven't felt a need to up the dose for years now. It does still have decongestant effects like the other two. Considering I'm caffeine dependent and can't cycle off daily intake without crippling headaches, where I cycle Dexedrine off on the weekends/holidays without any withdrawal effects, I'd have to agree: So long as it's a therapeutic dose it's on-par or safer than coffee.