4 ms·

Sometimes I wonder if NSAIDs are the same deal, or if there's just a subset of people they don't work well on.

by EamonnMR 5y ago

throwawayboise 5y ago
Tylenol (acetaminophen) does nothing for me. Advil (ibuprofen) does usually work. I used to get more headaches when I was younger, but I rarely get them now. Two things that have changed that might be related: I no longer use CRT screens, and I no longer drink diet soda (used to drink 4-6 cans a day, most days). Aside from headaches, Advil does better on other aches and pains than Tylenol, which does almost nothing. And it's better for the liver.
- genewitch 5y ago
  better for the liver, worse for the stomach. It's a sliding scale, you have to decide how much you care about whatever hurts not hurting anymore versus damage to organs you can't even see. Also i used to get wicked headaches from diet soda when i was younger, too. Is it possible to be "slightly" Phenylketonuric? I had to google the spelling, and it's interesting that "hyperactivity and behavioral issues" is listed as one of the symptoms. I doubt "slightly" is possible, that was tongue-in-cheek. Also as an aside, for pain that the standard dose of ibuprofen doesn't seem to help, emergency medicine studies have found that an additional standard dose of acetaminophen alongside the ibuprofen has greater pain reduction efficacy than vicodin.
JshWright 5y ago
There is a significant amount of evidence supporting the efficacy of NSAIDs. Note that they are more effective for some types of pain than others, due to the mechanism by which they work.
skyechurch 5y ago
NSAIDs and Tylenol definitely work differently on different people and on different types of pain ime. The stronger ones, like Torodol, can be very effective on even quite serious pain, but you can't even get it _with_ a prescription anymore in the USA.

4 ms·

Sometimes I wonder if NSAIDs are the same deal, or if there's just a subset of people they don't work well on.

by EamonnMR 5y ago

Sometimes I wonder if NSAIDs are the same deal, or if there's just a subset of people they don't work well on.

throwawayboise 5y ago
Tylenol (acetaminophen) does nothing for me. Advil (ibuprofen) does usually work. I used to get more headaches when I was younger, but I rarely get them now. Two things that have changed that might be related: I no longer use CRT screens, and I no longer drink diet soda (used to drink 4-6 cans a day, most days). Aside from headaches, Advil does better on other aches and pains than Tylenol, which does almost nothing. And it's better for the liver.
- genewitch 5y ago
  better for the liver, worse for the stomach. It's a sliding scale, you have to decide how much you care about whatever hurts not hurting anymore versus damage to organs you can't even see. Also i used to get wicked headaches from diet soda when i was younger, too. Is it possible to be "slightly" Phenylketonuric? I had to google the spelling, and it's interesting that "hyperactivity and behavioral issues" is listed as one of the symptoms. I doubt "slightly" is possible, that was tongue-in-cheek. Also as an aside, for pain that the standard dose of ibuprofen doesn't seem to help, emergency medicine studies have found that an additional standard dose of acetaminophen alongside the ibuprofen has greater pain reduction efficacy than vicodin.
JshWright 5y ago
There is a significant amount of evidence supporting the efficacy of NSAIDs. Note that they are more effective for some types of pain than others, due to the mechanism by which they work.
skyechurch 5y ago
NSAIDs and Tylenol definitely work differently on different people and on different types of pain ime. The stronger ones, like Torodol, can be very effective on even quite serious pain, but you can't even get it _with_ a prescription anymore in the USA.