That's not as bad as you might think, depending on your specific concern. We're basically worms with extra doodads glommed on. Cake hole connected to poop hole,

That's not as bad as you might think, depending on your specific concern. We're basically worms with extra doodads glommed on. Cake hole connected to poop hole, with gonads. Also, sometimes brains, but mostly gonads. Sorry, I don't know your level of knowledge of things cell-biology and genomics. If your concern is mouse != human, than that's not really a good argument by itself. If your concern is that many diseases / therapies that seem to work in mice don't readily translate to humans, then yeah, I agree.