It's "immune mediated", meaning that there is indeed a response by the immune system. Unsurprisingly, histamines and other inflammatory markers are detected. So

It's "immune mediated", meaning that there is indeed a response by the immune system. Unsurprisingly, histamines and other inflammatory markers are detected. Sometimes anti-inflammatories can help. https://en.m.wikipedia.org/wiki/Aquagenic_pruritus https://en.m.wikipedia.org/wiki/Aquagenic_pruritus