Space at the scale being discussed here is uniform, so no one direction should be "more populous" than another. The "empty" here designates an area without star

Space at the scale being discussed here is uniform, so no one direction should be "more populous" than another. The "empty" here designates an area without stars easily visible from Earth. Our local area is denser in our galactic plane, in the direction of our supercluster, etc. But 13 billion lightyears in ANY direction should look about the same.