I think the most widely accepted framework here suffices. The emperical framework. Cross breeding occurs slowly and is a long-used process. The long-used means

I think the most widely accepted framework here suffices. The emperical framework. Cross breeding occurs slowly and is a long-used process. The long-used means there is ample evidence suggesting cross-breeding results in safe food. The fact that cross breeding happens slowly gives any safety issues a long time to reveal themselves before it becomes wide-spread. Thus it makes sense that cross-breeding yields fewer unkown issues by the time its widespread. Essentially, early warning are built in, even for latent issues.