For one-off pieces with 2.54 or bigger spacing there is always the handmade old school tech - drawing the traces on copper laminate with marker pen, drilling h

For one-off pieces with 2.54 or bigger spacing there is always the handmade old school tech - drawing the traces on copper laminate with marker pen, drilling holes yourself and etching the board in ferric chloride. There is also a good old method using photo transfers and a laser printer if you not feeling like drawing it by hand. Still need to drill the holes yourself. You can re-use ferric chloride for many boards.