5 ms·

According to wikipedia: «Although curcumin has been assessed in numerous laboratory and clinical studies, it has no medical uses established by well-designed cl

by pingou 5y ago

According to wikipedia: «Although curcumin has been assessed in numerous laboratory and clinical studies, it has no medical uses established by well-designed clinical research. According to a 2017 review of more than 120 studies, curcumin has not been successful in any clinical trial, leading the authors to conclude that "curcumin is an unstable, reactive, non-bioavailable compound and, therefore, a highly improbable lead".» Not sure how accurate or up to date this wikipedia page is, though.

ekianjo 5y ago
> Not sure how accurate or up to date this wikipedia page is, though. Wikipedia is probably the last place I would check for scientific information.
- cashweaver 5y ago
  Why is that?
- notafraudster 5y ago
  Wikipedia isn't the source of the scientific information -- as is immediately apparent from the quoted sentence -- and I think basic media literacy requires that you not participate in the conversation if you can't parse that from the quote. The sources are this expensive review: https://pubs.acs.org/doi/10.1021/acs.jmedchem.6b00975 https://pubs.acs.org/doi/10.1021/acs.jmedchem.6b00975 And this related letter by the authors summarizing the review: https://pubs.acs.org/doi/10.1021/acsmedchemlett.7b00139 https://pubs.acs.org/doi/10.1021/acsmedchemlett.7b00139 High impact factor journal, at a basic scan the quote is accurate to the article, and the article uses standard methods. Authors all seem appropriately credentialled and working out of real institutions. Article itself has a high record of citation, and the constituent studies are all properly cited for you to proceed.
JeremyNT 5y ago
Examine has a summary of the research which provides some reason for optimism: https://examine.com/supplements/curcumin/ https://examine.com/supplements/curcumin/ It seems plausible that there could be something going on here, but as with most supplements there's not nearly enough data yet. I'd suggest that the "miraculous" effects the parent describes would more likely be attributed to placebo, though. These things tend to work around the margins, not with dramatic improvements, which is why they're hard to study.
- Damogran6 5y ago
  The problem here is that there’s lots of eyes on the problem, not all of them qualified, and there isn’t a body of work to lean on. Amyloid plaque removal was a strong contender for a bit, and there’s thinking that near 100% memory recovery will be possible when the root cause is addressed, and there’s a TON of attention in the space, but we’re not there yet.
- airbreather 5y ago
  Total BS, not placebo, I don't take shit if it doesn't have an impact that I can notice. I've been thru this before, studies this, studies that, you know, just try it, if it doesn't work for you don't continue. I just put my locksmith onto it today, he came around with his hand all swollen up, said he felt something go snap in it yesterday. I gave him 3 with a glass of milk and 20 minutes later he was already noticing improvement. Apparently it works by blocking the the inflammatory chemicals the body sends to an injury, but I'm just an electrical engineer so don't take anything I say about biochemistry seriously. Brand I like is Bioglan, double strength. I have put maybe 30 people onto it that have all had positive effects. A few years ago we went to Ulawatu in Bali and the chalet owner there was an old American guy Rob who had a disk injury from surfing years ago that flared up now and then and he was on some serious prescription anti-inflammatories, but they rendered him with serious cognitive difficulties. We have him some Curcumin and he said within the hour he could feel the pressure come off. When we left a few days later his Balinese wife was literally prostrate on the ground clutching feet and weeping with tears of thanks and appreciation. So if that's placebo, I'll take it anyway, but it's not. Sick of armchair experts that read a bunch of poorly execute studies and start spouting off claims, but never actually try it. The chances of harm are very low , and you might be surprised how effective it is because my experience, and that of many others, is that it beats anything prescription, for certain injuries, hands f$cking down. Placebo my arse.

by pingou 5y ago

ekianjo 5y ago

> Not sure how accurate or up to date this wikipedia page is, though. Wikipedia is probably the last place I would check for scientific information.

cashweaver 5y ago
Why is that?
notafraudster 5y ago
Wikipedia isn't the source of the scientific information -- as is immediately apparent from the quoted sentence -- and I think basic media literacy requires that you not participate in the conversation if you can't parse that from the quote. The sources are this expensive review: https://pubs.acs.org/doi/10.1021/acs.jmedchem.6b00975 https://pubs.acs.org/doi/10.1021/acs.jmedchem.6b00975 And this related letter by the authors summarizing the review: https://pubs.acs.org/doi/10.1021/acsmedchemlett.7b00139 https://pubs.acs.org/doi/10.1021/acsmedchemlett.7b00139 High impact factor journal, at a basic scan the quote is accurate to the article, and the article uses standard methods. Authors all seem appropriately credentialled and working out of real institutions. Article itself has a high record of citation, and the constituent studies are all properly cited for you to proceed.

JeremyNT 5y ago

Examine has a summary of the research which provides some reason for optimism: https://examine.com/supplements/curcumin/ https://examine.com/supplements/curcumin/ It seems plausible that there could be something going on here, but as with most supplements there's not nearly enough data yet. I'd suggest that the "miraculous" effects the parent describes would more likely be attributed to placebo, though. These things tend to work around the margins, not with dramatic improvements, which is why they're hard to study.

Damogran6 5y ago
The problem here is that there’s lots of eyes on the problem, not all of them qualified, and there isn’t a body of work to lean on. Amyloid plaque removal was a strong contender for a bit, and there’s thinking that near 100% memory recovery will be possible when the root cause is addressed, and there’s a TON of attention in the space, but we’re not there yet.
airbreather 5y ago
Total BS, not placebo, I don't take shit if it doesn't have an impact that I can notice. I've been thru this before, studies this, studies that, you know, just try it, if it doesn't work for you don't continue. I just put my locksmith onto it today, he came around with his hand all swollen up, said he felt something go snap in it yesterday. I gave him 3 with a glass of milk and 20 minutes later he was already noticing improvement. Apparently it works by blocking the the inflammatory chemicals the body sends to an injury, but I'm just an electrical engineer so don't take anything I say about biochemistry seriously. Brand I like is Bioglan, double strength. I have put maybe 30 people onto it that have all had positive effects. A few years ago we went to Ulawatu in Bali and the chalet owner there was an old American guy Rob who had a disk injury from surfing years ago that flared up now and then and he was on some serious prescription anti-inflammatories, but they rendered him with serious cognitive difficulties. We have him some Curcumin and he said within the hour he could feel the pressure come off. When we left a few days later his Balinese wife was literally prostrate on the ground clutching feet and weeping with tears of thanks and appreciation. So if that's placebo, I'll take it anyway, but it's not. Sick of armchair experts that read a bunch of poorly execute studies and start spouting off claims, but never actually try it. The chances of harm are very low , and you might be surprised how effective it is because my experience, and that of many others, is that it beats anything prescription, for certain injuries, hands f$cking down. Placebo my arse.