No question Alzheimer's is a tragedy played out much too often. It's also a tremendously complex condition that's been the focus of research for decades. Infla

No question Alzheimer's is a tragedy played out much too often. It's also a tremendously complex condition that's been the focus of research for decades. Inflammation contributes greatly to the disease burden of many conditions. Of course people vary in terms of inflammatory status. A moderate number of studies have shown omega-3 supplementation can reduce onset of some brain conditions, e.g., schizophrenia. In line with the mouse model it's well-accepted that inflammatory processes are implicated in AD. Microglial response triggers pro-inflammatory factors in turn leading to accumulation of toxic proteins in cortical neurons. Here's a succinct review of the subject: [0]. Anti-inflammatory agents have been associated preventative effects, e.g., NSAIDs though trials of these drugs haven't shown benefit. Omega-3 fatty acids have received a lot of study re: anti-inflammatory effects, particularly in cardiovascular disease. In AD some observational studies have shown reduction in risk of developing AD which is encouraging, however placebo-controlled studies have produced equivocal results, so the question remains open how much benefit omega-3 provides. This articles reviews the omega-3 evidence [1]. OTOH everyone seems to agree omega-3 intake through diet or supplementation will at least do no harm. On the whole diets higher in long-chain omega-3 fatty acids is likely to be most effective. Foods such as fish/seafood and green-leafy vegetables are good sources. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214864/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214864/ [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747747/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747747/