Yes, if it has the 'right' properties to pass through mucosa and the BBB, it's absolutely possible. How else would insufflated drugs like cocaine work? There a

Yes, if it has the 'right' properties to pass through mucosa and the BBB, it's absolutely possible. How else would insufflated drugs like cocaine work? There are a number of nasal sprays that act on the CNS. Bupreborphine nasal spray is pretty common as a fast acting overdose treatment that also acts on the central nervous system.