3 ms·
A self-administered nasal spray is really gonna get appreciable amounts to the brain? I'm skeptical. Why not an infusion into the cerebrospinal fluid, or a topi
by lr4444lr 5y ago
A self-administered nasal spray is really gonna get appreciable amounts to the brain? I'm skeptical. Why not an infusion into the cerebrospinal fluid, or a topical ultrasound guided injection through a thinner, softer area of the skull?
- perrylaj 5y agoYes, if it has the 'right' properties to pass through mucosa and the BBB, it's absolutely possible. How else would insufflated drugs like cocaine work? There are a number of nasal sprays that act on the CNS. Bupreborphine nasal spray is pretty common as a fast acting overdose treatment that also acts on the central nervous system.