To maximize safety: 1 - don't eat or drink for at least 4 or 5 hours beforehand, so there's nothing in your stomach to vomit 2 - lie in the recovery position

To maximize safety: 1 - don't eat or drink for at least 4 or 5 hours beforehand, so there's nothing in your stomach to vomit 2 - lie in the recovery position ( https://en.wikipedia.org/wiki/Recovery_position https://en.wikipedia.org/wiki/Recovery_position ) with one's mouth facing downwards to minimize the chance of aspirating any liquid 3 - don't move around 4 - be with a trained, trusted, and experienced practitioner, who you've vetted thoroughly and who you are sure can keep you safe 5 - again, don't mix substances!