I worked one place that did so. Our traffic was sharded over a couple dozen sites, but combined we were at US top-100 scale. Every site was on a very large bar

I worked one place that did so. Our traffic was sharded over a couple dozen sites, but combined we were at US top-100 scale. Every site was on a very large bare metal box (sites were grouped together when possible, IIRC only one required it’s own dedicated machine). Each box was a special snowflake. The DBs were on separate hardware. When I left they were starting to embrace containerized microservices.