I ran into this and I run some flavor of Dvorak on everything. Once I got my Zsa keyboards (first an Ergodox then a Moonlander, I love both but slightly prefer

I ran into this and I run some flavor of Dvorak on everything. Once I got my Zsa keyboards (first an Ergodox then a Moonlander, I love both but slightly prefer the moonlander) I added a level shift which makes it issue Command+<qwerty letter>. You can do the same with a regular keyboard in linux (haven't tried but I know it's possible with xkb) or mac (karabiner I think?). I have 16 layers of possible keys activated by thumb chords (though in practice my brain runs out of awareness of different combos far before my ~1000 unique keys). So I just dedicate a layer to this pseudo-qwerty. Need to get around to writing that emoji layer...