Just to add my two cents as someone who recently switched to Colemak-DH after getting a moonlander (I used a das ultimate for years though), but I am currently

Just to add my two cents as someone who recently switched to Colemak-DH after getting a moonlander (I used a das ultimate for years though), but I am currently typing this on my laptop using QWERTY. I feel like switching between the two isn't always 100% painless with a small lag time especially if I've been away from one or the other a few days while using the other one predominantly. But generally it's not too bad. The worst of it being typing on my laptop, messaging friends late at night and having a sudden forgetfulness which is easily overcome by just looking at the keyboard for a moment while typing till my hands remember.