3 ms·

I agree about you second point. I was too quick to make my comment and I was conflating stuff I've read about nasal esketamine, which didn't have as robust evid

I agree about you second point. I was too quick to make my comment and I was conflating stuff I've read about nasal esketamine, which didn't have as robust evidence behind it as i.v. ketamine. I should not write comments while holding a baby that is trying to sleep and failing at it. About the first point, I still disagree with the parent comment. The standard 0,5mg/kg ketamine is given under 40 minutes. I've seen two patients receive it. The room was dimly lit, silent and peaceful, as to not induce or exacerbate any possible dissociative or hallucinative side effects. The patients didn't report any side effects at first and later reported a little sedation. I wouldn't be a able to tell with certainty if they had received a placebo or ketamine, and certainly not within minutes. Source: psychiatrist in training Edit: I still think we need hard data about anti-suicide effect and not just surrogate markers. Variability in suicidal ideation is suggested to be a predictor of suicide attempts [1]. If ketamine first gets someone better and later on they relapse, they could, in theory, be at increased risk for suicide. More long term data is also needed about it's long term effects. Note that I do think it's a good thing that ketamine is becoming more available! I will continue to suggest it for e.g. patients with treatment resistant and severe depression. [1] https://www.sciencedirect.com/science/article/abs/pii/S0165032705001527 https://www.sciencedirect.com/science/article/abs/pii/S01650...

ketamine 5y ago
Source: patient taking infusions. .5 mg/kg I was numb all over, my lips tongue and throat were numb. I melted in to the chair and felt like I was up down and sideways at the same time. You would not be able to tell immediately but I put on my blindfold within 7 minutes due to effects starting.
- Forbo 5y ago
  I've had to vouch for four of your comments now. Looks like you account was shadow banned. Maybe contact @dang to see if they'll fix it?
- hadmatter 5y ago
  Thanks, I appreciate your comment and experience. I agree that if one was to get those effects, one would be quite unlikely to suspect placebo. I hope you got the help you needed from ketamine.
Perenti 5y ago
It sounds like those patients were in a very nice calm place. During my K infusions (30-50mg/hr for 7 days) for chronic neuropathic pain I was in a single room in a hospital. There was enough to see and hear that the mind took them and ran with them. I had a fight with a shower curtain because it said I wasn't clean yet. I had conversations with my toothbrush and hairbrush. It took 24 hours for my daughter's reporting that a puppy had died to make sense. And I'm not drug naive by a very long shot. On my 2nd infusion there was an older gentleman across the hall from me who had never had anything stronger than scotch whiskey. He was not having a good time at all. 7 days falling in and out of the K-hole while hallucinating is not as much fun as it sounds.

ketamine 5y ago

Source: patient taking infusions. .5 mg/kg I was numb all over, my lips tongue and throat were numb. I melted in to the chair and felt like I was up down and sideways at the same time. You would not be able to tell immediately but I put on my blindfold within 7 minutes due to effects starting.

Forbo 5y ago
I've had to vouch for four of your comments now. Looks like you account was shadow banned. Maybe contact @dang to see if they'll fix it?
hadmatter 5y ago
Thanks, I appreciate your comment and experience. I agree that if one was to get those effects, one would be quite unlikely to suspect placebo. I hope you got the help you needed from ketamine.

Perenti 5y ago

It sounds like those patients were in a very nice calm place. During my K infusions (30-50mg/hr for 7 days) for chronic neuropathic pain I was in a single room in a hospital. There was enough to see and hear that the mind took them and ran with them. I had a fight with a shower curtain because it said I wasn't clean yet. I had conversations with my toothbrush and hairbrush. It took 24 hours for my daughter's reporting that a puppy had died to make sense. And I'm not drug naive by a very long shot. On my 2nd infusion there was an older gentleman across the hall from me who had never had anything stronger than scotch whiskey. He was not having a good time at all. 7 days falling in and out of the K-hole while hallucinating is not as much fun as it sounds.