> My psychiatrist does IV ketamine treatments for depression. I'm not sure what dosage she uses, but from what she's told me, it's not a drug trip, and a lot o

> My psychiatrist does IV ketamine treatments for depression. I'm not sure what dosage she uses, but from what she's told me, it's not a drug trip, and a lot of people don't feel any different during the treatment. At 0.5mg/kg intravenous, there's no way that people wouldn't feel anything. It's not necessarily a "drug trip", but pretty much anybody can tell the difference between that large of a dose of ketamine vs. a saline solution. For trials in cases like this, it's common to use a group which receives either a smaller dose of the drug or a drug that is intended to mimic some of the subjectively observable side effects.