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> As Drew Weissman, one of the physician-scientists who helped develop mRNA vaccine technology put it, “mRNA vaccines are essentially plug and play. We believe
by sjmm1989 5y ago
> As Drew Weissman, one of the physician-scientists who helped develop mRNA vaccine technology put it, “mRNA vaccines are essentially plug and play. We believe you can change the part of the mRNA that encodes a protein, plugging in new code specific to the virus we hope to protect against, and cause one’s body to produce proteins that match that virus’ proteins. We do not have to develop and manufacture an entirely new formula.”
I think this quote sufficiently answers your curiosity slightly. Not a lot, but slightly.
- zpeti 5y agoI don’t think it does. With dengue fever the issue is once you develop antibodies the first time, the second time you get infected the antibodies actually increase the viruses chances of binding to whatever it binds to, so the effectiveness of the virus increases. I’m not sure how mRNA vaccines get around that, but I imagine they have a plan, it would be interesting to hear it.
- esyir 5y agoUnfortunately not, I'm aware of how the mrna vaccines work. The issue with dengue in particular is a bit of a special case. Infection with a single serotype weakens the body against infection with other serotypes. Now. This poses a challenge to vaccination, as you need to find a way to get all four. Currently, we have dengvaxia, which does do that. However, an interesting effect is that the vaccination is only useful if you already have a history of dengue. If you're dengue naive, the vaxx increases the risk of severe disease instead.
- sjmm1989 5y ago> However, an interesting effect is that the vaccination is only useful if you already have a history of dengue. If you're dengue naive, the vaxx increases the risk of severe disease instead. I was concerned about this potentially being a thing with Covid at one point. Thankfully not the case, but yeah...