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The work from Dr. Sinclair, and various other scientist seems to agree that its not just weight and body shape, you actually live longer and have less illnesses

by seer 5y ago

The work from Dr. Sinclair, and various other scientist seems to agree that its not just weight and body shape, you actually live longer and have less illnesses throughout your life. Really fascinating stuff - the Lifespan podcast really changed how I think about all of this. I'm like you and haven't had breakfast in quite a while, but recently started skipping launch as well. A lot harder, but supposedly will feel about the same when my body adjusts.

arboghast 5y ago
Except that in his podcast he spreads a lot of bad science. I'd even call it misinformation. The work on Sirtuins role in health span and life span is, at most, inconclusive. Multiple studies on trans-resveratrol failed to show any improvement whatsoever (and yes, even when mixed with a fat to increase bioavailability). Maybe NMN does something, maybe not. It's not yet clear. He states everything as facts while most of his own studies have never been successfully replicated, even disproven in some cases. I'd take everything he says with a grain of salt. He's been called out multiple times by his peers, including his own friends like Matt Kaeberlein.
- puchatek 5y ago
  The most recent claim for bio availability of resveratrol seems to be that you need to pair it with piperine. Yep. Just like Curcumin. I'm sure there's some science to back it up but it still brings to mind that old Marc Maron sketch.
- Alc0r 5y ago
  He’s done a lot for mainstream interest in gerontology and longevity research but it’s pretty clear at this point that he’s financially tied to his position, there are multiple companies worth millions that develop products based on his labs research. So he’d rather block everyone who tries to challenge him on Twitter and claim certainty on his podcast than be objective about the data.
- seer 5y ago
  _Obviously_ until conclusive double blind controlled studies have been done, this is all hypothesis. The science behind the "longevity clock check" with by testing methaliations seems legit though doesn't it? I'm just a dude on the internet so would love some advice from somebody in the field. But if that test is real, then it's a mater of time now isn't it? We wouldn't need to wait decades for people to die off so we can prove anything, we can just test with this clock, and in a couple of years we'll have results. I for one am quite excited about the whole thing. While in his book he is less so, I think he seems pretty straight forward on his podcast by what has been tested with what, and how dubious the science of the various claims is. He admits a lot about some mechanism that they have no idea how it works, just that it does in various model organisms. Anyway fasting and exercise have been linked to longevity for literally millennia by various religions largely unconnected with each other. I gather that we're now just trying to understand the mechanisms how all of this actually works. I personally am trying the things on myself that have been proven to not cause harm, and seeing how it affects me. For now I've settled on reduced sugar in my diet, cut out gluten, stoped doing breakfast, started excising and do an occasional (2-3 times a year 4+ days water fasting). Seems to have kept the gray out of my hair for now - a lot of the friends in my age group already have it. Will see how that "no lunch" affects to me. All anecdotal of course.
bumby 5y ago
What is the main mechanism behind the claim? I've heard it may have to do with the fact that catabolic conditions correlate to a longer lifepan. With that said, I'm sure there are people who (at least occasionally) want to be in an anabolic state, so I wonder how to balance those conflicting goals. E.g., can you get similar effects by creating a catabolic window for a few months every year?
- deleted 5y ago
  [deleted]
lancesells 5y ago
I'm not doctor but I why skip lunch if it's hard to do? Eat something healthy and enjoy your time and days spent on the earth. I'm not saying ignore eating healthy or exercising. Those are key but punishing yourself to optimize for the possibility of living longer is a weird one. Especially since diet science seems to be far from perfect.
- deleted 5y ago
  [deleted]
- mtberatwork 5y ago
  I generally agree with you, but for me I'm not necessarily trying to optimize for an ultra long life span but instead am trying to optimize for going out peacefully. I don't want my end years to be in some miserable, decrepit state in which I am unable to do much. In the end, all we can hope for is a peaceful exit.
- seer 5y ago
  What I gather is that eating less = living longer, and living better. Skipping lunch "feels hard" only at first, supposedly. Friends have been doing the no lunch thing for other reasons and report that after several weeks you just don't feel the need to lunch at all. For me that sounds like a little bit of hardship now, for a big gain afterwards. I get the time to think about / prepare lunch back, and can now enjoy my dinners way more, as I don't need to really think and restrain myself on how much I eat then. Obviously I wouldn't trade feeling bad for the rest of my life for a longer life, but it seems that's not what's happening, hopefully. It's more like "invest a bit of pain now, gain a lot of pleasure later" kinda dynamic. But I'm in the middle of this thing though so we'll see :)
01100011 5y ago
Sinclair is getting in trouble lately for his questionable research. Look into the spat between Dr. Charles Brenner and Sinclair over unsubstantiated and low quality research claims. Sinclair finally blocked Brenner and others on Twitter because they kept calling out his frauds.

by seer 5y ago

arboghast 5y ago

Except that in his podcast he spreads a lot of bad science. I'd even call it misinformation. The work on Sirtuins role in health span and life span is, at most, inconclusive. Multiple studies on trans-resveratrol failed to show any improvement whatsoever (and yes, even when mixed with a fat to increase bioavailability). Maybe NMN does something, maybe not. It's not yet clear. He states everything as facts while most of his own studies have never been successfully replicated, even disproven in some cases. I'd take everything he says with a grain of salt. He's been called out multiple times by his peers, including his own friends like Matt Kaeberlein.

puchatek 5y ago
The most recent claim for bio availability of resveratrol seems to be that you need to pair it with piperine. Yep. Just like Curcumin. I'm sure there's some science to back it up but it still brings to mind that old Marc Maron sketch.
Alc0r 5y ago
He’s done a lot for mainstream interest in gerontology and longevity research but it’s pretty clear at this point that he’s financially tied to his position, there are multiple companies worth millions that develop products based on his labs research. So he’d rather block everyone who tries to challenge him on Twitter and claim certainty on his podcast than be objective about the data.
seer 5y ago
_Obviously_ until conclusive double blind controlled studies have been done, this is all hypothesis. The science behind the "longevity clock check" with by testing methaliations seems legit though doesn't it? I'm just a dude on the internet so would love some advice from somebody in the field. But if that test is real, then it's a mater of time now isn't it? We wouldn't need to wait decades for people to die off so we can prove anything, we can just test with this clock, and in a couple of years we'll have results. I for one am quite excited about the whole thing. While in his book he is less so, I think he seems pretty straight forward on his podcast by what has been tested with what, and how dubious the science of the various claims is. He admits a lot about some mechanism that they have no idea how it works, just that it does in various model organisms. Anyway fasting and exercise have been linked to longevity for literally millennia by various religions largely unconnected with each other. I gather that we're now just trying to understand the mechanisms how all of this actually works. I personally am trying the things on myself that have been proven to not cause harm, and seeing how it affects me. For now I've settled on reduced sugar in my diet, cut out gluten, stoped doing breakfast, started excising and do an occasional (2-3 times a year 4+ days water fasting). Seems to have kept the gray out of my hair for now - a lot of the friends in my age group already have it. Will see how that "no lunch" affects to me. All anecdotal of course.

bumby 5y ago

What is the main mechanism behind the claim? I've heard it may have to do with the fact that catabolic conditions correlate to a longer lifepan. With that said, I'm sure there are people who (at least occasionally) want to be in an anabolic state, so I wonder how to balance those conflicting goals. E.g., can you get similar effects by creating a catabolic window for a few months every year?

deleted 5y ago
[deleted]

lancesells 5y ago

I'm not doctor but I why skip lunch if it's hard to do? Eat something healthy and enjoy your time and days spent on the earth. I'm not saying ignore eating healthy or exercising. Those are key but punishing yourself to optimize for the possibility of living longer is a weird one. Especially since diet science seems to be far from perfect.

deleted 5y ago
[deleted]
mtberatwork 5y ago
I generally agree with you, but for me I'm not necessarily trying to optimize for an ultra long life span but instead am trying to optimize for going out peacefully. I don't want my end years to be in some miserable, decrepit state in which I am unable to do much. In the end, all we can hope for is a peaceful exit.
seer 5y ago
What I gather is that eating less = living longer, and living better. Skipping lunch "feels hard" only at first, supposedly. Friends have been doing the no lunch thing for other reasons and report that after several weeks you just don't feel the need to lunch at all. For me that sounds like a little bit of hardship now, for a big gain afterwards. I get the time to think about / prepare lunch back, and can now enjoy my dinners way more, as I don't need to really think and restrain myself on how much I eat then. Obviously I wouldn't trade feeling bad for the rest of my life for a longer life, but it seems that's not what's happening, hopefully. It's more like "invest a bit of pain now, gain a lot of pleasure later" kinda dynamic. But I'm in the middle of this thing though so we'll see :)

01100011 5y ago

Sinclair is getting in trouble lately for his questionable research. Look into the spat between Dr. Charles Brenner and Sinclair over unsubstantiated and low quality research claims. Sinclair finally blocked Brenner and others on Twitter because they kept calling out his frauds.