5 ms·

There’s a strong evidence base for correlation, the base for causation is much worse. Only few things like bone health in the elderly have been shown to be impr

There’s a strong evidence base for correlation, the base for causation is much worse. Only few things like bone health in the elderly have been shown to be improved by supplementation.

sooheon 5y ago
This very post references a randomized, double blind, placebo controlled trial. It's an intervention over 5+ years that showed 22% reduction in autoimmune disease, not a correlative study.
- legulere 5y ago
  It’s a study wether vitamin D prevents cancer and cardiovascular diseases: https://clinicaltrials.gov/ct2/show/NCT01169259 https://clinicaltrials.gov/ct2/show/NCT01169259 The results are negative: https://pubmed.ncbi.nlm.nih.gov/30415629/ https://pubmed.ncbi.nlm.nih.gov/30415629/ What you see here is that combing through the data to see wether anything shows a publishable correlation. It’s better than a correlation in the general population, but can be also spurious. Here is the article: https://pubmed.ncbi.nlm.nih.gov/35082139/ https://pubmed.ncbi.nlm.nih.gov/35082139/ It’s important to observe that “omega 3 fatty acid supplementation with or without vitamin D reduced the autoimmune disease rate by 15% (not statistically significant)”. If vitamin D reduced autoimmune diseases you would expect omega 3 + vitamin D to have similar results than just vitamin D
  - sooheon 5y ago
    > Here is the article: https://pubmed.ncbi.nlm.nih.gov/35082139/ https://pubmed.ncbi.nlm.nih.gov/35082139/ It’s important to observe that “omega 3 fatty acid supplementation with or without vitamin D reduced the autoimmune disease rate by 15% (not statistically significant)”. There are two endpoints measured, and you chose to quote the statistically insignificant result, rather than the significant one. Though I agree, p-hacking is always an issue. OTOH, plenty of biological discoveries come from unintended observations. As long as they replicate, nothing's off limits -- you wouldn't disbelieve penicillin because it wasn't discovered in a pre-registered trial. > If vitamin D reduced autoimmune diseases you would expect omega 3 + vitamin D to have similar results than just vitamin D It did. D only hazard ratio: .68, D+omega3 hazard ratio .69

There’s a strong evidence base for correlation, the base for causation is much worse. Only few things like bone health in the elderly have been shown to be improved by supplementation.

sooheon 5y ago

This very post references a randomized, double blind, placebo controlled trial. It's an intervention over 5+ years that showed 22% reduction in autoimmune disease, not a correlative study.

legulere 5y ago
It’s a study wether vitamin D prevents cancer and cardiovascular diseases: https://clinicaltrials.gov/ct2/show/NCT01169259 https://clinicaltrials.gov/ct2/show/NCT01169259 The results are negative: https://pubmed.ncbi.nlm.nih.gov/30415629/ https://pubmed.ncbi.nlm.nih.gov/30415629/ What you see here is that combing through the data to see wether anything shows a publishable correlation. It’s better than a correlation in the general population, but can be also spurious. Here is the article: https://pubmed.ncbi.nlm.nih.gov/35082139/ https://pubmed.ncbi.nlm.nih.gov/35082139/ It’s important to observe that “omega 3 fatty acid supplementation with or without vitamin D reduced the autoimmune disease rate by 15% (not statistically significant)”. If vitamin D reduced autoimmune diseases you would expect omega 3 + vitamin D to have similar results than just vitamin D
- sooheon 5y ago
  > Here is the article: https://pubmed.ncbi.nlm.nih.gov/35082139/ https://pubmed.ncbi.nlm.nih.gov/35082139/ It’s important to observe that “omega 3 fatty acid supplementation with or without vitamin D reduced the autoimmune disease rate by 15% (not statistically significant)”. There are two endpoints measured, and you chose to quote the statistically insignificant result, rather than the significant one. Though I agree, p-hacking is always an issue. OTOH, plenty of biological discoveries come from unintended observations. As long as they replicate, nothing's off limits -- you wouldn't disbelieve penicillin because it wasn't discovered in a pre-registered trial. > If vitamin D reduced autoimmune diseases you would expect omega 3 + vitamin D to have similar results than just vitamin D It did. D only hazard ratio: .68, D+omega3 hazard ratio .69