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> The polio vaccines we currently use are imperfect Is that due to tradeoffs (cost, health risk, etc.) with other types of vaccines, or do we simply not know h

• beagle3 5y ago
  They are non-sterilizing ; that is, they protect the vaccinee from getting the disease, but not from getting (and shedding) the virus. We have sterilizing oral ones. They have safety issues, both personal and population level ones. The essentially perfect way is to give everyone the non-sterilizing one as early as possible in life, and the sterilizing one at a later stage. The non-sterilizing one protects against the safety issues in the sterilizing one.