> Remember, the protein-folding software works by analogy to known structures, which for the bulk of proteins can take you quite far (with ingenious software an

> Remember, the protein-folding software works by analogy to known structures, which for the bulk of proteins can take you quite far (with ingenious software and lots of processing power). But they will not create new protein folds ex nihilo. This is only true if you take AlphaFold or RosettaFold into consideration. However, there are protein design software suites (including Rosetta, which is part of RosettaFold) able to generate de novo protein folds not found in natural proteins[1]. Furthermore, many of those models have been demonstrated, using experimental methods, to adopt the desired structure in solution. [1]: Here’s an early example - https://www.science.org/doi/10.1126/science.1089427 https://www.science.org/doi/10.1126/science.1089427