With things like the Iron Dome and Patriot Missile System I'm certain the US has the capability to knock some number of incoming nuclear weapons out of the sky.

With things like the Iron Dome and Patriot Missile System I'm certain the US has the capability to knock some number of incoming nuclear weapons out of the sky. People in rural and even suburban areas in the US will probably be fine, maybe lose a few years life expectancy due to cancers and the like.