3 ms·

I cannot metabolize short chain fatty acids well and they all come from plant food. Is the cellular mechanism for this known? I seem to have trouble processing

I cannot metabolize short chain fatty acids well and they all come from plant food. Is the cellular mechanism for this known? I seem to have trouble processing long chain triglycerides and I do better with animal fats, like butter and bacon. Any resources you could link to or thoughts you might share on this detail would be potentially of value to me for better understanding my genetic disorder and practical approaches to managing it with diet.

astrange 5y ago
Digestion relies on your gut microbiome and how much fiber you eat; both those things are much more variable than your DNA and so are more likely to be personalized to you than anything else is. Unless you actually had a medical-grade genetic test?
- FollowingTheDao 5y ago
  Yes, full genome from Nebula genomics. Take a look at what it means to be a FUT2 non-secretor and you will soon see how much genetics plays a role. Knowing this cured MY IBS. I am in no way saying it is everyones issue, but it was mine. https://www.sciencedirect.com/science/article/abs/pii/S1673852721002617?dgcid=rss_sd_all https://www.sciencedirect.com/science/article/abs/pii/S16738... https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094863 https://journals.plos.org/plosone/article?id=10.1371/journal... https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020113 https://journals.plos.org/plosone/article?id=10.1371/journal... We know the genome changes so much of us, from our eye color to height to susceptibility to ideas. Why would it not also determine what foods we should eat?
FollowingTheDao 5y ago
First, I am not talking about the metabolism of triglycerides, only the metabolism off PUFA. And can you give me an example of what you mean by "I seem to have trouble processing long chain triglycerides", and what genetic disorder? But yes, very will known. There are thee enzymes, FADS1, FADS2, and EVOL5 that turn the short chain fatty acids like ALA in flax seed into the DHA you find in fish. The FADS genes are the most studied and polymorphisms in the genes have been linked to different cultures and therefor the reliance on certain fatty acids. https://www.researchgate.net/figure/Dietary-sources-and-metabolic-pathway-of-PUFAs_fig2_256502287 https://www.researchgate.net/figure/Dietary-sources-and-meta... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371589/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371589/

astrange 5y ago

Digestion relies on your gut microbiome and how much fiber you eat; both those things are much more variable than your DNA and so are more likely to be personalized to you than anything else is. Unless you actually had a medical-grade genetic test?

FollowingTheDao 5y ago
Yes, full genome from Nebula genomics. Take a look at what it means to be a FUT2 non-secretor and you will soon see how much genetics plays a role. Knowing this cured MY IBS. I am in no way saying it is everyones issue, but it was mine. https://www.sciencedirect.com/science/article/abs/pii/S1673852721002617?dgcid=rss_sd_all https://www.sciencedirect.com/science/article/abs/pii/S16738... https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094863 https://journals.plos.org/plosone/article?id=10.1371/journal... https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020113 https://journals.plos.org/plosone/article?id=10.1371/journal... We know the genome changes so much of us, from our eye color to height to susceptibility to ideas. Why would it not also determine what foods we should eat?

FollowingTheDao 5y ago

First, I am not talking about the metabolism of triglycerides, only the metabolism off PUFA. And can you give me an example of what you mean by "I seem to have trouble processing long chain triglycerides", and what genetic disorder? But yes, very will known. There are thee enzymes, FADS1, FADS2, and EVOL5 that turn the short chain fatty acids like ALA in flax seed into the DHA you find in fish. The FADS genes are the most studied and polymorphisms in the genes have been linked to different cultures and therefor the reliance on certain fatty acids. https://www.researchgate.net/figure/Dietary-sources-and-metabolic-pathway-of-PUFAs_fig2_256502287 https://www.researchgate.net/figure/Dietary-sources-and-meta... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371589/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371589/