Sure. In the last 100 years, "bohr's" non-deterministic quantum physics has all but overtaken "einstein's" deterministic physics. The final nail in the coffin f

Sure. In the last 100 years, "bohr's" non-deterministic quantum physics has all but overtaken "einstein's" deterministic physics. The final nail in the coffin for einstein will be a theory of quantum gravity. Can't get a bigger paradigm shift than switching from a deterministic to a non-deterministic world.