It's quite interesting. I'm not sure that broad use of Win32/Wine for all types of GUIs would even work well for things like apps communicating with the broader

It's quite interesting. I'm not sure that broad use of Win32/Wine for all types of GUIs would even work well for things like apps communicating with the broader desktop, and accessibility -- never mind that the desktop software stack is already a crumbling tower of complexity. But I can see it being attractive for full attention/fullscreen apps (like games) that don't use those things or by design bring their own implementations for those things, where the benefit is the reduced decision space for the developer, at the cost of the increased complexity. However, as the article states, ports are often using "compatibility layers" that are just worse versions of Wine though, so for such quasi-ports, there really is no increased complexity in using Wine instead.