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Gut Microbiota Regulate Pancreatic Growth, Exocrine Function and Gut Hormones

55 points by voisin 5y ago

fortysixdegrees 5y ago
Would love for an easier to follow explanation of this
- darig 5y ago
- pmarreck 5y ago
  A diet change (specifically a high-fat diet or HFD, thinking "keto" here) led to a doubling in size of the pancreas, but it wasn't clear to me what that means as far as obesity or prediabetic implications (is a doubled-up pancreas conducive, or unfavorable, to fat retention?) They then took the resulting gut microflora and transplanted them to another organism and observed similar effects on the pancreas That's about all I got out of it, not sure what it broadly means though other than that the gut microflora keep having a seemingly greater effect on our overall health than we think
sebow 5y ago
Without dismissing the empirical evidence and importancy of the study, these are not that surprising: after all the gut is very linked to eating, and from the start of the abstract it somewhat relates: you could imagine people who suffer from obesity or diabetes changed this 'collection of microbes' over time into this negative feedback loop that then alters a multitude of systems. For those who have not kept up on it, there are more obscure studies recently done:which found that the gut microbiota affect all sorts of things: from blood pressure to brain functions that can then degenerate into 'mild' things (depression for example) or more severe cases (symptoms akin to autism or even worse).Somehow on a second thought one could argue these all make sense, because these alter your hormonal balance, every disease can possible appear.And it's cliche but it's true: we are what we eat,if these microorganisms don't function properly, you're at a disadvantage.(It's also one of the reasons nutrition is so important when you talk about bodybuilding, or any other activity/goal that needs to be reached through having a proper hormonal balance) Even though it's not present here, I dislike the rhetoric that seems to portray such organisms as "scary" distinct parts from our bodies(especially when talked in the media).Without these microbes we would have a lot of problems adapting to our environment, if one could even exist without them.
- ljlolel 5y ago
  > Even though it's not present here, I dislike the rhetoric that seems to portray such organisms as "scary" distinct parts from our bodies(especially when talked in the media).Without these microbes we would have a lot of problems adapting to our environment, if one could even exist without them. Was this written by gut microbes?
  - eyelidlessness 5y ago
    Either that or an AI. But I’m leaning towards gut microbes. (To be clear/ruin any potential humor in this reply, I’m in agreement with “you are what you eat” in this context and treating “written by gut microbes” as “written by the human host of those microbes”)
umbula 5y ago
...in mice.
yosito 5y ago
As someone who has been dealing with mysterious gut issues since May, I am glad this sort of research is being done, I just wish it were something with more clear answers and solutions for suffering people.
- diamondage 5y ago
  Have you looked at sungenomics? They've worked wonders with my partners IBS.

55 points by voisin 5y ago

fortysixdegrees 5y ago

Would love for an easier to follow explanation of this

darig 5y ago
pmarreck 5y ago
A diet change (specifically a high-fat diet or HFD, thinking "keto" here) led to a doubling in size of the pancreas, but it wasn't clear to me what that means as far as obesity or prediabetic implications (is a doubled-up pancreas conducive, or unfavorable, to fat retention?) They then took the resulting gut microflora and transplanted them to another organism and observed similar effects on the pancreas That's about all I got out of it, not sure what it broadly means though other than that the gut microflora keep having a seemingly greater effect on our overall health than we think

sebow 5y ago

Without dismissing the empirical evidence and importancy of the study, these are not that surprising: after all the gut is very linked to eating, and from the start of the abstract it somewhat relates: you could imagine people who suffer from obesity or diabetes changed this 'collection of microbes' over time into this negative feedback loop that then alters a multitude of systems. For those who have not kept up on it, there are more obscure studies recently done:which found that the gut microbiota affect all sorts of things: from blood pressure to brain functions that can then degenerate into 'mild' things (depression for example) or more severe cases (symptoms akin to autism or even worse).Somehow on a second thought one could argue these all make sense, because these alter your hormonal balance, every disease can possible appear.And it's cliche but it's true: we are what we eat,if these microorganisms don't function properly, you're at a disadvantage.(It's also one of the reasons nutrition is so important when you talk about bodybuilding, or any other activity/goal that needs to be reached through having a proper hormonal balance) Even though it's not present here, I dislike the rhetoric that seems to portray such organisms as "scary" distinct parts from our bodies(especially when talked in the media).Without these microbes we would have a lot of problems adapting to our environment, if one could even exist without them.

ljlolel 5y ago
> Even though it's not present here, I dislike the rhetoric that seems to portray such organisms as "scary" distinct parts from our bodies(especially when talked in the media).Without these microbes we would have a lot of problems adapting to our environment, if one could even exist without them. Was this written by gut microbes?
- eyelidlessness 5y ago
  Either that or an AI. But I’m leaning towards gut microbes. (To be clear/ruin any potential humor in this reply, I’m in agreement with “you are what you eat” in this context and treating “written by gut microbes” as “written by the human host of those microbes”)

umbula 5y ago

...in mice.

yosito 5y ago

As someone who has been dealing with mysterious gut issues since May, I am glad this sort of research is being done, I just wish it were something with more clear answers and solutions for suffering people.

diamondage 5y ago
Have you looked at sungenomics? They've worked wonders with my partners IBS.