3 ms·
That just means its being read right? Is there a surprise or unexpected outcome in that paper? Its hard for me to tell.
by vmception 5y ago
That just means its being read right?
Is there a surprise or unexpected outcome in that paper? Its hard for me to tell.
- TeeMassive 5y agoNo, mRNA is meant to be temporary. Here the furthers the findings of another study showing that the corresponding DNA sequence was found in some cells: > Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells > We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptas > We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure. But don't freak out, the study begins by stating that it is temporary.
- JPLeRouzic 5y agoI am not a biologist but what I understand is that the mRNA of the vaccine is reversed transcripted and somehow incorporated in the genome of the host: "Our study shows that BNT162b2 can be reverse transcribed to DNA in liver cell line Huh7, and this may give rise to the concern if BNT162b2-derived DNA may be integrated into the host genome" Reverse transcriptase creates double-stranded DNA from an RNA template. I think a caveat is that this study is done in-vitro in cells (carcinoma cell line) with a behavior very different from the cells in our body.