This is wise and comprehensive HN comment. My only recommendation is to realize that no human ever sits right on a high dimensional mean or median. You are all

This is wise and comprehensive HN comment. My only recommendation is to realize that no human ever sits right on a high dimensional mean or median. You are all unique! The variances explained by the statistical models of longevity and health are generally woefully low. Don’t even talk about correlation for populations unless you add the “variance explained” and unless you are sure the statical model and cofactors apply broadly. You, as an individual, may be way out in metabolic and life-style left field. Are these recommendations even of the correct polarity for you? We raised 80 different strains of inbred mice on both standard and very high fat (60% calories from lard) diets. Each strain was randomly assign to either diet for life with about 8 to 10 replicate “identical twins” per diet. Do you think we can make a dietary recommendation for mouse number 81? Well at a crude level, sure. The high fat diet generally is not a good diet in terms of lifespan. But there are big deviations from the mean and at least one strain lived much longer on the ridiculous high fat diet than on the standard chow diet. Paper by Roy S et al 2021 in Nature Metabolism, and open in bioRxiv: https://www.biorxiv.org/content/10.1101/776559v3 https://www.biorxiv.org/content/10.1101/776559v3