3 ms·
I’m having trouble getting the patent to load on my phone, but my interpretation of the “codon optimized” patented sequence is that although the sequence codes
by rflrob 5y ago
I’m having trouble getting the patent to load on my phone, but my interpretation of the “codon optimized” patented sequence is that although the sequence codes for a naturally occurring protein sequence, the RNA triplets that are actually used are not naturally occurring.
MolBio 102 for software engineers: each amino acid is coded for by 3 RNA bases. However, the number of possible RNA triplets (4^3=64) is greater than the number of amino acids (20), so some amino acids have multiple triplets assigned to them. For instance, both UUA and CUG code for the same amino acid (leucine), but one of them is more efficient to express. The implicit argument is that consistent preferential use of these optimal codons is evidence of genetic engineering rather than natural evolution.