True, but without Anycast you wont' be able to control which server users query, and your latency for EU or APAC users will probably be in the range of 200-800m

True, but without Anycast you wont' be able to control which server users query, and your latency for EU or APAC users will probably be in the range of 200-800ms. Route 53 uses Anycast network infrastructure with many geographically dispersed POPs so users will hit the closest POP dramatically reducing latency. For $200/mo you could host a hundred domains and billions of queries with much better performance using Route 53.