4 ms·
Does it really matter that it's resistant to BA.1 induced humoral immunity? From the BA.1 variant we learned that cell mediated immunity is more important to e
by xiphias2 5y ago
Does it really matter that it's resistant to BA.1 induced humoral immunity?
From the BA.1 variant we learned that cell mediated immunity is more important to end the pandemic.
The media got very loud that the 4th vaccine doesn't help to stop people from getting sick, but it required a month more data to see that it is worth to be injected to decrease the probability of serious illness / death.
- data_acquired 5y agoYeah, its not clear if preventing symptomatic infection is as crucial an end-point in contrast to preventing hospitalization, the latter of which is indeed mediated by T-cell immunity rather than antibody titers. The following detail is worth noting though --- "Vaccine sera were collected from sixteen vaccinees four weeks after the second vaccination with mRNA-1273 (Moderna)" So it seems like they haven't tested against sera from people who got three doses? Response to BA.1 was better with three doses than two, but I think if the data from Israel was to go by, the impact of the third dose on antibody titers also waned over time (although T-cell mediated immunity stayed the same in terms of % hospitalized).
- rastignack 5y ago> Response to BA.1 was better with three doses than two Not under 60, though.
- EdwardDiego 5y agoSource?