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City of Hope Medical Center is developing the PIpepTolDC "inverse vaccine" to treat Type 1 Diabetes and other auto-immune diseases [0]. They have had two succes
by mleonhard 5y ago
City of Hope Medical Center is developing the PIpepTolDC "inverse vaccine" to treat Type 1 Diabetes and other auto-immune diseases [0]. They have had two successful trials in humans [1, 2]. The third trial is recruiting adults with T1D onset 1-4 years ago [3].
The PIpepTolDC treatment is expensive because it is labor intensive. A technician must take some of the patient's blood, isolate their immune cells, replicate the cells, desensitize them, and then inject them back into the patient. BioNTech is developing a new category of treatments for auto-immune diseases [4] which should be inexpensive injections. These should include a treatment for Type 1 Diabetes.
Frankly, this tech seems amazing and ready to cure many diseases. The pace of development seems slow. I wish there were some way to speed it up. About 80,000 children develop T1D every year.
[0] https://www.precisionvaccinations.com/type-1-diabetes-vaccine-candidate-launches-usa-study https://www.precisionvaccinations.com/type-1-diabetes-vaccin...
[1] https://doi.org/10.1126/scitranslmed.aaf7779 https://doi.org/10.1126/scitranslmed.aaf7779
[2] https://doi.org/10.1016/S2213-8587(20)30104-2 https://doi.org/10.1016/S2213-8587(20)30104-2
[3] https://clinicaltrials.gov/ct2/show/NCT04590872 https://clinicaltrials.gov/ct2/show/NCT04590872
[4] https://investors.biontech.de/news-releases/news-release-details/biontech-publishes-data-novel-mrna-vaccine-approach-treat https://investors.biontech.de/news-releases/news-release-det...