I don't think it's very difficult. In the ii-V-I, slightly shifting the root of the ii sounds fine, and most other problems can be solved similarly. I've made p

I don't think it's very difficult. In the ii-V-I, slightly shifting the root of the ii sounds fine, and most other problems can be solved similarly. I've made plenty of music in just intonation, here's a recent example: https://www.youtube.com/watch?v=qkUs-BdxtN8 https://www.youtube.com/watch?v=qkUs-BdxtN8 To me it sounds like very standard harmony, but "cleaner".