4 ms·
Also looks to be a significant MAOI from the data table at the end. MAOIs are known to be antidepressants; I'm not sure if they addressed this in the paper as a
by sterlind 5y ago
Also looks to be a significant MAOI from the data table at the end. MAOIs are known to be antidepressants; I'm not sure if they addressed this in the paper as a confounding factor.
- ggm 5y agoI wouldn't exactly call this an antagonistic behaviour. If it can provide some immediate relief by virtue of being an MAOI antidepressant, and promote the kind of brain plasticity to help people make better pathways, isn't that actually good? If you meant "it might be that it helped but not because of neuroplasticity effects" you could be right. But assuming they have good basis to think it does, I don't see being an MAOI as a confounding effect in outcome.
- elevaet 5y agoMAOIs can be dangerous too, certain combinations with strong MAOIs can be problematic. Foods containing tyramime and many drugs don't play nicely with MAOIs.
- jmcgough 5y agoThere are a number of researchers now who believe that the risk of MAOIs is overblown, for example: https://pubmed.ncbi.nlm.nih.gov/30255284/ https://pubmed.ncbi.nlm.nih.gov/30255284/
- actually_a_dog 5y agoThat's not what your link says. The claim there is that MAOIs are less dangerous today than in the past because the tyramine content of food has been significantly reduced. In particular cheese, which it says was the only food associated with fatalities due to hypertension, now presents much less of a danger than before.
- gehwartzen 5y agoThere are newer classes of of MAOIs called Reversible Selective MAOIs (Moclobemide) that do not have this problem with tyramine containing food.