4 ms·
This is not supported by the literature as far as I'm aware, do you have a source? Propofol, the most common adult surgical anesthetic, decreases neuronal activ
by oarabbus_ 5y ago
This is not supported by the literature as far as I'm aware, do you have a source? Propofol, the most common adult surgical anesthetic, decreases neuronal activity via the mechanism of making it harder for action potentials to fire [0], and has a litany of effects few of which are excitatory , and generally correlated to decreasing cortical activity [1].
And ketamine, the most common pediatric and veterinary anesthetic, has a complex mechanism of action acting on GABA, NMDA, and other receptor systems, often with generally inhibitory characteristics [2] and with definite decrease in brain activity in animal models [3].
[0] https://www.ncbi.nlm.nih.gov/books/NBK430884/ https://www.ncbi.nlm.nih.gov/books/NBK430884/
[1] https://elifesciences.org/articles/60824#:~:text=The%20broad%20range%20of%20dynamics,with%20the%20slow%2Ddelta%20oscillation https://elifesciences.org/articles/60824#:~:text=The%20broad....
[2] https://journals.lww.com/anesthesia-analgesia/Fulltext/1998/11000/KetamineTeaching_an_Old_Drug_New_Tricks.39.aspx https://journals.lww.com/anesthesia-analgesia/Fulltext/1998/...
[3] https://www.sciencedirect.com/science/article/abs/pii/0028390868900671 https://www.sciencedirect.com/science/article/abs/pii/002839...