I think there's an argument to be made that a working opioid system is central to the anti-depressant effect of any anti-depressant? I actually tried naltrexone

I think there's an argument to be made that a working opioid system is central to the anti-depressant effect of any anti-depressant? I actually tried naltrexone for a condition related to depression and it made me feel much worse and unable to feel much pleasure in anything. DMX is really a crappy drug with a half-life that is too long for frequent administration.