2 ms·
I wonder if a bone marrow transplant from resistant donor is going to be an option one day.
by f6v 5y ago
I wonder if a bone marrow transplant from resistant donor is going to be an option one day.
- abcc8 5y agoOne of the big issues with this approach is that you have to effectively kill the person's immune system with very high dose chemo before introducing the resistant bone marrow cells. While BM transplantation is routinely performed, there are instances where the transplant is not successful (for reasons other than HLA match, etc), with the failure of bone marrow engraftment being typically fatal. Given this, and that the current anti-retroviral drugs generally work pretty well (i.e. those taking the medication enjoy a reduced risk of mortality), this curative treatment might not be pursued.
- BizarroLand 5y agoIt's worked in the past at least twice, but then instead of well-controlled HIV you have to deal with Graft vs Host disease which is much more problematic. https://www.npr.org/sections/health-shots/2019/03/05/700361887/bone-marrow-transplant-renders-second-patient-free-of-hiv https://www.npr.org/sections/health-shots/2019/03/05/7003618...
- peter303 5y agoA quarter of recipients die the first year after a bone marrow transplant. Survival taking AIDS drugs is much higher like 97%.