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You’re making a good point that’s usually ignored outside of genomics. Inside genomics, alignment is treated, correctly, as a probabilistic rather than determin
by Q6T46nT668w6i3m 5y ago
You’re making a good point that’s usually ignored outside of genomics. Inside genomics, alignment is treated, correctly, as a probabilistic rather than deterministic process (i.e., an alignment is not “right” or “wrong”) and many choose to consider multiple alignments.
- jacquesm 5y agoThat works as long as you don't try to do things like phylogenetic trees, the ordering becomes so critical that even one swap can make things look like the order was the reverse. Of course you should never rely on just the one datum but the temptation to do so and to treat the software as correct is large due to the pressure to publish rather than to hold back and wait until there are multiple pieces of evidence.
- Q6T46nT668w6i3m 5y agoAre you speaking from experience?
- jacquesm 5y agoI was first hand witness to some stuff that I doubt would withstand prodding but I'm not at liberty to talk about it.