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Though this study did not focus on other cancers, THC's adverse effect might not be limited to just HPV-related head and neck cancer. From the paper[1]: "Simi

Though this study did not focus on other cancers, THC's adverse effect might not be limited to just HPV-related head and neck cancer. From the paper[1]: "Similar to CNR1, the cannabinoid receptor CNR2 was also found to be highly expressed and correlated with worse prognosis in tumors such as breast cancer (16), renal cancer (17), lung cancer (51), and HNSCC (21). In our study, the expression of CNR2 mRNA was upregulated in HNSCC compared with normal samples, and much higher in HPV-positive HNSCC samples. Meanwhile, knockdown of the expression of CNR2 inhibited the proliferation of HPV-positive HNSCC in vitro and in vivo. In addition, the selective CNR2 agonist Hu308 increased the growth, migration, and inhibited the apoptosis of HPV-positive HNSCC cells, whereas the selective CNR2 antagonist SR144528 exhibited an opposite effect. These phenomena were also observed in other tumors such as colon cancer, in which CNR2 activation promoted cancer progression via the AKT/GSK3β signaling pathway when cannabinoids used in concentrations similar to those in marijuana exposure (42)." I hope someone with a background in this area can thoroughly evaluate this paper and explain to us laymen how reliable they think its methods and conclusions are. I also hope followup studies are done, particularly in humans, as this study was only carried out in cells and in mice. As someone fighting cancer, this study worries me, despite the study being only done on cells and mice, and despite anti-drug research having a disgraceful history, which usually makes me take such studies with a grain of salt. [1] - https://clincancerres.aacrjournals.org/content/26/11/2693 https://clincancerres.aacrjournals.org/content/26/11/2693

Terry_Roll 5y ago
You might want to ask your medical expert about this. Penicillin based anti biotics break down into penicillamine https://wikidiff.com/penicillin/penicillamine https://wikidiff.com/penicillin/penicillamine "penicillamine treatment relies on its binding to accumulated copper and elimination through urine." https://en.wikipedia.org/wiki/Penicillamine https://en.wikipedia.org/wiki/Penicillamine "Copper deficiency reduces interleukin-2 (IL-2) production and IL-2 mRNA in human T-lymphocytes" https://pubmed.ncbi.nlm.nih.gov/9039825/ https://pubmed.ncbi.nlm.nih.gov/9039825/ "In preclinical and early clinical studies, local application of IL-2 in the tumor has been shown to be clinical more effective in anticancer therapy than systemic IL-2 therapy, over a broad range of doses, without serious side effects." https://en.wikipedia.org/wiki/Interleukin_2#Medical_use https://en.wikipedia.org/wiki/Interleukin_2#Medical_use I'm left wondering if the medical experts should be telling us to consume copper supplements after being on a course of penicillin based antibiotics to reduce our risk of cancer! IL-2 not only has a role in cancer treatment, but by regulating the white blood cells, how useful is this for old age problems like (rheumatoid) arthritis and other things like that? Salt (sodium chloride) will increase some CD4 cells in a dose dependent manner to a point. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541612 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541612 https://pubmed.ncbi.nlm.nih.gov/30116758/ https://pubmed.ncbi.nlm.nih.gov/30116758/ I know other chemicals vit K2-mk4 will reduce the inflammatory effect in RA (synovial cells), and RA may be the result of not enough of vit K2-mk4 which then increases demand for copper. K2-mk4 so far as I can tell is the only fat soluble vitamin which is stored in bone and also induces apoptosis in hepatocellular carcinoma, leukemia, and MDS cell lines. https://pubmed.ncbi.nlm.nih.gov/18484089 https://pubmed.ncbi.nlm.nih.gov/18484089 This is just one pathway of many many in the body. Medicine is a type of chemical programming/hacking.
- selimthegrim 5y ago
  Wouldn’t you want to stay copper depleted? I don’t follow.
  - Terry_Roll 5y ago
    Copper depleted for what?

Terry_Roll 5y ago

You might want to ask your medical expert about this. Penicillin based anti biotics break down into penicillamine https://wikidiff.com/penicillin/penicillamine https://wikidiff.com/penicillin/penicillamine "penicillamine treatment relies on its binding to accumulated copper and elimination through urine." https://en.wikipedia.org/wiki/Penicillamine https://en.wikipedia.org/wiki/Penicillamine "Copper deficiency reduces interleukin-2 (IL-2) production and IL-2 mRNA in human T-lymphocytes" https://pubmed.ncbi.nlm.nih.gov/9039825/ https://pubmed.ncbi.nlm.nih.gov/9039825/ "In preclinical and early clinical studies, local application of IL-2 in the tumor has been shown to be clinical more effective in anticancer therapy than systemic IL-2 therapy, over a broad range of doses, without serious side effects." https://en.wikipedia.org/wiki/Interleukin_2#Medical_use https://en.wikipedia.org/wiki/Interleukin_2#Medical_use I'm left wondering if the medical experts should be telling us to consume copper supplements after being on a course of penicillin based antibiotics to reduce our risk of cancer! IL-2 not only has a role in cancer treatment, but by regulating the white blood cells, how useful is this for old age problems like (rheumatoid) arthritis and other things like that? Salt (sodium chloride) will increase some CD4 cells in a dose dependent manner to a point. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541612 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541612 https://pubmed.ncbi.nlm.nih.gov/30116758/ https://pubmed.ncbi.nlm.nih.gov/30116758/ I know other chemicals vit K2-mk4 will reduce the inflammatory effect in RA (synovial cells), and RA may be the result of not enough of vit K2-mk4 which then increases demand for copper. K2-mk4 so far as I can tell is the only fat soluble vitamin which is stored in bone and also induces apoptosis in hepatocellular carcinoma, leukemia, and MDS cell lines. https://pubmed.ncbi.nlm.nih.gov/18484089 https://pubmed.ncbi.nlm.nih.gov/18484089 This is just one pathway of many many in the body. Medicine is a type of chemical programming/hacking.

selimthegrim 5y ago
Wouldn’t you want to stay copper depleted? I don’t follow.
- Terry_Roll 5y ago
  Copper depleted for what?