4 ms·

Antihistamines show promise in treating long Covid-19 symptoms

7 points by pesfandiar 5y ago

colechristensen 5y ago
Case study, by nurses, n=2, both middle aged women However large effect size, using relatively safe otc meds Very vulnerable to placebo effects, random chance, or comorbid with other issues
- ameminator 5y ago
  Wow, that's disappointing. It probably warrants further investigation, but I don't see how something with only 2 datapoints can be meaningfully published.
  - AnimalMuppet 5y ago
    It can be meaningfully published as "someone should look into this". That's not nothing.
  - colechristensen 5y ago
    It can be meaningfully published as a case study, that’s what those are. One or a very small number of cases and what happened. It happens in medicine all the time.
airbreather 5y ago
Don't know if it would help, but Curcumin (tumeric extract with a pepper extract to potentiate it) is a near magic anti-inflammatory. It's totally over the counter and without side effects afaik. I have dozens of stories about it, just one is guy I worked with was taking Voltaren 2-3 times a day for his shoulder, hadn't played golf for two years. I gave him some and he played golf the next day. He then went for holidays to UK where his sister and her husband are both doctors and they were taking it prophylactically against early onset Alzheimer's. It has to have the pepper extract with it to be effective, if you have a sprain or similar it acts in 1-3 hours. Could be helpful for long covid, chances of harm very low.
hogrider 5y ago
Still get covid headaches 8 months post infection, definitely gonna try this.
- airbreather 5y ago
  something to consider, despite these being more targeted at initial infection, I'd be trying https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-620008 https://pesquisa.bvsalud.org/global-literature-on-novel-coro... https://www.cureus.com/articles/68407-turmeric-as-a-possible-treatment-for-covid-19-induced-anosmia-and-ageusia https://www.cureus.com/articles/68407-turmeric-as-a-possible... https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04924-9 https://trialsjournal.biomedcentral.com/articles/10.1186/s13...
airbreather 5y ago
I see a downvote occured - use of curcumin is not without precedent and some reasonable possibility, plus it is hard to find any serious evidence of harm caused by taking it. Seems more likely than the antihistamine story, based on stats. https://www.researchgate.net/publication/341513369_Potential_effects_of_curcumin_in_the_treatment_of_COVID_-19_infection https://www.researchgate.net/publication/341513369_Potential... https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-620008 https://pesquisa.bvsalud.org/global-literature-on-novel-coro... https://www.cureus.com/articles/68407-turmeric-as-a-possible-treatment-for-covid-19-induced-anosmia-and-ageusia https://www.cureus.com/articles/68407-turmeric-as-a-possible...

7 points by pesfandiar 5y ago

Case study, by nurses, n=2, both middle aged women However large effect size, using relatively safe otc meds Very vulnerable to placebo effects, random chance, or comorbid with other issues

ameminator 5y ago
Wow, that's disappointing. It probably warrants further investigation, but I don't see how something with only 2 datapoints can be meaningfully published.
- AnimalMuppet 5y ago
  It can be meaningfully published as "someone should look into this". That's not nothing.
- colechristensen 5y ago
  It can be meaningfully published as a case study, that’s what those are. One or a very small number of cases and what happened. It happens in medicine all the time.

airbreather 5y ago

Don't know if it would help, but Curcumin (tumeric extract with a pepper extract to potentiate it) is a near magic anti-inflammatory. It's totally over the counter and without side effects afaik. I have dozens of stories about it, just one is guy I worked with was taking Voltaren 2-3 times a day for his shoulder, hadn't played golf for two years. I gave him some and he played golf the next day. He then went for holidays to UK where his sister and her husband are both doctors and they were taking it prophylactically against early onset Alzheimer's. It has to have the pepper extract with it to be effective, if you have a sprain or similar it acts in 1-3 hours. Could be helpful for long covid, chances of harm very low.

hogrider 5y ago

Still get covid headaches 8 months post infection, definitely gonna try this.

airbreather 5y ago
something to consider, despite these being more targeted at initial infection, I'd be trying https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-620008 https://pesquisa.bvsalud.org/global-literature-on-novel-coro... https://www.cureus.com/articles/68407-turmeric-as-a-possible-treatment-for-covid-19-induced-anosmia-and-ageusia https://www.cureus.com/articles/68407-turmeric-as-a-possible... https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04924-9 https://trialsjournal.biomedcentral.com/articles/10.1186/s13...

airbreather 5y ago

I see a downvote occured - use of curcumin is not without precedent and some reasonable possibility, plus it is hard to find any serious evidence of harm caused by taking it. Seems more likely than the antihistamine story, based on stats. https://www.researchgate.net/publication/341513369_Potential_effects_of_curcumin_in_the_treatment_of_COVID_-19_infection https://www.researchgate.net/publication/341513369_Potential... https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-620008 https://pesquisa.bvsalud.org/global-literature-on-novel-coro... https://www.cureus.com/articles/68407-turmeric-as-a-possible-treatment-for-covid-19-induced-anosmia-and-ageusia https://www.cureus.com/articles/68407-turmeric-as-a-possible...