Yes and no. One could create a Squid SSL-Bump (MITM) proxy and create ACL's that operate closely to uBlock. There won't be full parity between the two so uBlo

Yes and no. One could create a Squid SSL-Bump (MITM) proxy and create ACL's that operate closely to uBlock. There won't be full parity between the two so uBlock would still provide some benefit to the client. The method of using Squid as a MITM proxy method assumes one can install and trust a server public key into the clients. Squid will limit what HTTP protocols one could use. e.g. h2, alpn won't be supported. If one does not mind those limitations and having to maintain a small list of sites to bypass MITM due to public key pinning then Squid can have rules for anything the client or server can see. Domains, URL's, Content-Type, Size, Methods, Ports, you name it. One could save some bandwidth on static content as an additional benefit.