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Maybe I'm dumb, but I don't fully understand what this means: "controlling for vaccination as a time-varying covariate." Reading your citation it sounds like t
by cantspeakmind85 5y ago
Maybe I'm dumb, but I don't fully understand what this means: "controlling for vaccination as a time-varying covariate."
Reading your citation it sounds like they did not have a control group of people infected but unvaccinated?
- ceejayoz 5y agoIt absolutely means they "have a control group of people infected but unvaccinated". As it's not a clinical trial, that means they have the vaccination status as a value in the data being analyzed, and are able to account for its effects in their analysis, and did so.
- cantspeakmind85 5y agoI don't think it does. They cite table 21 for this analysis: https://static-content.springer.com/esm/art%3A10.1038%2Fs41591-022-01689-3/MediaObjects/41591_2022_1689_MOESM1_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs415... If you read their footnotes, they say: "In total, 95,223 (61.93%) participants in COVID-19 group received COVID-19 vaccine (42,065 (44.18%), 45,450 (47.73%) and 7708 (8.09%) received BNT162b2, mRNA-1273 and Ad26.COV2.S, respectively) and 3,173,169 (56.29%) participants in contemporary group received COVID-19 vaccine (1,349,844 (42.54%), 1,609,399 (50.72%) and 213,926 (6.74%) received BNT162b2, mRNA-1273 and Ad26.COV2.S, respectively) before end of follow up." So it looks like both the COVID-19 group and contemporary group had received the covid vaccine.
- ceejayoz 5y agoWhat part of "61.93% [of] participants ... received COVID-19 vaccine" is confusing to you? Both the "got COVID" and the "didn't get COVID" ("contemporary control") group had some people vaccinated and some not. They can slice and dice the data based on vaccination status; they clearly have the info.