This might have less to do with caffeine and more to do with brewed coffee’s fat-soluble monoamine oxidase inhibitors that tend to accumulate in brain tissues a

This might have less to do with caffeine and more to do with brewed coffee’s fat-soluble monoamine oxidase inhibitors that tend to accumulate in brain tissues and have a half-life of months. The anxiogenic effects of norharman and harman are somewhat well documented, and both of them are found in coffee brews in high amounts.