https://www.nature.com/articles/d41586-021-02903-x https://www.nature.com/articles/d41586-021-02903-x it is called Gain of Function research, when zoonotic vir

https://www.nature.com/articles/d41586-021-02903-x https://www.nature.com/articles/d41586-021-02903-x it is called Gain of Function research, when zoonotic viruses (such as bats coronavirus) are grafted with proteins (such as Spike protein and its furin cleavage motif) that make it extremely virulent to humans. Such research on coronaviruses historically has been done at labs in USA and China and considered extremely dangerous (https://www.nature.com/articles/nature.2015.18787 https://www.nature.com/articles/nature.2015.18787) quoting https://inference-review.com/article/thunder-out-of-china https://inference-review.com/article/thunder-out-of-china "You can manipulate [coronaviruses] in the lab pretty easily, it is the spike protein drives a lot of what happens with the coronavirus zoonotic risk. You can get the sequence, you can build the protein. We worked with Ralph Baric at UNC who did this, insert into a backbone of another virus and do some work in the lab. So, you can get more predictive when you find a sequence. … The logical progression for vaccines — if you are going to develop a vaccine for SARS, people are going to use pandemic SARS, but let’s try to insert some of these [other spike genes] and get a better vaccine [72]"